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You are here: Home / Wellness / Lifestyle and Your Brain
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Lifestyle and Your Brain

March 2, 2024 · In: aging, cognitive function, dementia, health, health span, Lifestyle, Wellness


DO YOU EVER WONDER IF YOUR DAILY CHOICES could be the secret sauce to outsmarting time? I do. Today I explore a new study examining the relationship between lifestyle and brain function.

I care deeply about my future cognitive health. So, I was excited to discover a new study that shows an association between lifestyle and better cognitive functioning in older adults.

Right up my alley.


Brace yourselves for a mind-blowing revelation — a study has spilled the beans on a recipe for cognitive wizardry, and it’s simpler than you think.

Forget magic potions; we’re talking about the enchantment of fruits, veggies, and a daily dose of movement.

Two cherries. Fruit and vegetable consumption may lower your risk of cognitive decline.
Photo by Quaritsch Photography on Unsplash

I will explore a new study that examines whether the accumulation of dementia-related pathologies in the brain may impact the association between a healthy lifestyle and better cognitive functioning in older adults.

TL;DR — Fast facts

If you are short of time, I’ve got you covered. Here’s a quick rundown of the key points.

In the intricate tapestry of cognitive function, the researchers discovered the following:

  • Lifestyle emerged as the maestro, orchestrating over 88 percent of the global cognition score.
  • Less than 12 percent of global cognition appeared to be influenced by beta-amyloid (BAY-tuh AM-uh-loyd). Plaques formed when these protein pieces called beta-amyloid clump together. Beta-amyloid comes from a larger protein in the fatty membrane surrounding nerve cells.

To defend against cognitive decline in aging, we should adopt a healthy lifestyle, which includes a nutritious diet, exercise, and moderate alcohol intake.

Grab your fork, tie those shoelaces, and let the adventure begin — because who knew your brain’s best friends were hiding in your salad bowl and at the gym door?

Study details

In a recent study featured in JAMA Neurology, scientists dived into the question of how our brain’s health dance might be affected by some unwanted party crashers called dementia-related issues.

Imagine this: leading a healthy lifestyle is like throwing a fantastic party for your brain.

Micrograph showing amyloid beta (brown) in amyloid plaques of the brain (upper left of image).
Micrograph showing amyloid beta (brown) in amyloid plaques of the brain (upper left of image) and cerebral blood vessels (right of image). https://en.wikipedia.org/wiki/Amyloid_beta

But what if uninvited guests (those pesky dementia-related things) try to spoil the fun?

This study aimed to determine if these brain interlopers can mess with the positive vibes that a healthy lifestyle brings to the cognitive table, especially in our elders.

Study details

Picture this: a group of researchers peeked into the lives of 754 folks who’ve left us as part of a Rush Memory and Aging Project.

This project is like a time-traveling detective story that started in 1997 and went to 2022, investigating what happens in our brains over time.

A barren tree, arms extended. Black and white image.
Photo by Ron Szalata on Unsplash

These participants had their memories checked while alive and their brains closely examined after they passed away — it’s like a final brain report card. 

The researchers did all this detective work from January to June 2023 to understand how our lifestyle choices affect our brain health, even after we’ve left the stage of life.

More study details

The researchers created a personal health scorecard to evaluate lifestyle choices systematically.

First, the non-smoking achievement is a crucial step in the right direction.

Then, it’s about hitting the weekly exercise quota of 150 minutes of physical activity. 

Two glasses of wine. Excessive wine consumption can harm cognitive functioning.
Photo by Sérgio Alves Santos on Unsplash

Responsible alcohol consumption is another key aspect — moderation is the name of the game. 

The dietary component involves adhering to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet with a score higher than 7.5. 

Lastly, keeping the mind engaged with cognitive activities adds to the score. The range is from 0 to 5; a higher score signifies a more health-conscious lifestyle. It’s essentially a systematic way of gauging how well you align your choices with a healthier, more vibrant you.

Study results

The researchers discovered this:

In aging, a robust defense against cognitive decline emerges from embracing a healthy lifestyle — think wholesome diets, regular exercise, and moderate alcohol consumption.

Two older people sit in silhouette under a tree, facing away from us, as the sun sits in the distance.
Photo by Harli Marten on Unsplash

What’s truly intriguing is that even in the presence of Alzheimer’s disease pathology or other complications like beta-amyloid load and phosphorated tau tangles, the positive impact of a healthy lifestyle on cognitive function remains unwavering. 

It’s like having a shield that persists against the challenges of aging.

Furthermore, as if delivering a preventive punch, a higher healthy lifestyle score correlates with a lower beta-amyloid load in the brain, emphasizing the potential role of healthy living in fending off cognitive issues. 

My thoughts – Lifestyle and your brain

The study authors concluded the following:

In older adults, a healthy lifestyle may provide a cognitive reserve to maintain cognitive abilities independently of common neuropathologies of dementia.

This recent study brings valuable evidence to the ongoing debate surrounding modifiable risk factors and their impact on reducing the risk of Alzheimer’s disease. 

I will continue to eat well, get physical activity, and avoid excessive alcohol consumption (truth be told, I don’t drink). 

Add in sleep well and remain intellectually engaged, and I have a pathway to minimizing cognitive loss over time.

A person sits on the right end of a bench as she peers outside of a large window. We see water in the distance.
Photo by Maria Teneva on Unsplash

Takeaway messages – Lifestyle and your brain

The findings contribute significantly to our understanding of how certain factors within our control can play a crucial role in mitigating the risk of developing Alzheimer’s, offering essential insights for future discussions and potential interventions.

Still, it’s crucial to approach the research findings cautiously, especially considering the study’s cross-sectional design.

Follow me

If you enjoyed this essay, please consider following me:

Thank you for reading “Mind Over Matter: The Kaleidoscope of Cognitive Clarity through Healthy Living.”

Brain Hacks

By: Dr. Michael Hunter · In: aging, cognitive function, dementia, health, health span, Lifestyle, Wellness · Tagged: diet, exercise, exercise and health, fitness, fitness and health, health, lifestyle, lifestyle and cognitve function, wellness

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Your go-to source for all things wellness. I am Michael Hunter. I practice radiation oncology in the Seattle area and have a particular interest in health. I am delighted that you have joined me here. Thank you.

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